Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus.
Identifieur interne : 000E49 ( Main/Exploration ); précédent : 000E48; suivant : 000E50Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus.
Auteurs : M. Jallouli [France] ; L. Galicier [France] ; N. Zahr [France] ; O. Aumaître [France] ; C. Francès [France] ; V. Le Guern [France] ; F. Lioté [France] ; A. Smail [France] ; N. Limal [France] ; L. Perard [France] ; H. Desmurs-Clavel [France] ; D. Le Thi Huong [France] ; B. Asli [France] ; J-E Kahn [France] ; J. Pourrat [France] ; L. Sailler [France] ; F. Ackermann [France] ; T. Papo [France] ; K. Sacré [France] ; O. Fain [France] ; J. Stirnemann [Suisse] ; P. Cacoub [France] ; G. Leroux [France] ; J. Cohen-Bittan [France] ; J. Sellam [France] ; X. Mariette [France] ; B. Blanchet [France] ; J S Hulot [France] ; Zahir Amoura [France] ; J C Piette [France] ; N. Costedoat-Chalumeau [France] ; Aurelien Delluc [France]Source :
- Arthritis & rheumatology [ 2326-5205 ] ; 2015-04-30.
Abstract
Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. Therefore, interest in blood HCQ concentration measurement has increased, but little is known about factors that influence blood HCQ concentration variability. This study was undertaken to analyze determinants of blood HCQ concentrations. We conducted a retrospective analysis of patient data, including data from the Plaquenil Lupus Systemic (PLUS) study, to determine the association of epidemiologic, clinical, and biologic factors with blood HCQ concentrations. Data for nonadherent patients (blood HCQ concentration <200 ng/ml) were excluded. To examine homogeneous pharmacologic data, we restricted the analyses of the PLUS data to the 509 SLE patients receiving 400 mg/day. We found no association of ethnicity or smoking with blood HCQ concentrations and no pharmacokinetic drug-drug interaction with antacids or with inhibitors or inducers of cytochrome P450 enzymes. On multivariate analysis, high body mass index (P = 0.008), no treatment with corticosteroids (P = 0.04), increased time between the last tablet intake and measurement of blood HCQ concentrations (P = 0.017), low platelet count (P < 0.001), low neutrophil count (P < 0.001), and high estimated creatinine clearance (P < 0.001) were associated with low blood HCQ concentrations. In 22 SLE patients with chronic renal insufficiency (median serum creatinine clearance 52 ml/minute [range 23-58 ml/minute]) who received 400 mg/day HCQ, the median blood HCQ concentration was significantly higher than that in the 509 patients from the PLUS study (1,338 ng/ml [range 504-2,229 ng/ml] versus 917 ng/ml [range 208-3316 ng/ml]) (P < 0.001). We provide a comprehensive analysis of determinants of blood HCQ concentrations. Because this measurement is increasingly being used, these data might be useful for clinicians.
Url:
DOI: 10.1002/art.39194
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000070
- to stream Hal, to step Curation: 000070
- to stream Hal, to step Checkpoint: 000096
- to stream Main, to step Merge: 000E50
- to stream Main, to step Curation: 000E49
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus.</title><author><name sortKey="Jallouli, M" sort="Jallouli, M" uniqKey="Jallouli M" first="M" last="Jallouli">M. Jallouli</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192648" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-301664" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Galicier, L" sort="Galicier, L" uniqKey="Galicier L" first="L" last="Galicier">L. Galicier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-212052" status="OLD"> <orgName>Service d'Immunopathologie [Hôpital Saint-Louis, Paris]</orgName> <date type="end">2019-12-31</date> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300301" type="direct"></relation> <relation active="#struct-523767" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-523767" type="direct"><org type="institution" xml:id="struct-523767" status="VALID"> <orgName>CHU Saint Louis [APHP]</orgName> <desc> <address> <addrLine>Hôpital Saint Louis,1 avenue Claude Vellefaux75010 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Zahr, N" sort="Zahr, N" uniqKey="Zahr N" first="N" last="Zahr">N. Zahr</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-428299" status="INCOMING"> <orgName>UF pharmacologie et pharmacogénétique</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Aumaitre, O" sort="Aumaitre, O" uniqKey="Aumaitre O" first="O" last="Aumaître">O. Aumaître</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-232091" status="INCOMING"> <orgName>Service de médecine interne, hôpital Gabriel-Montpied</orgName> <desc> <address> <addrLine>Service de médecine interne, hôpital Gabriel-Montpied, 58, rue Montalembert, 63003 Clermont-Ferrand cedex 1, France</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300144" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID"> <orgName>CHU Clermont-Ferrand</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Frances, C" sort="Frances, C" uniqKey="Frances C" first="C" last="Francès">C. Francès</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19449" status="OLD"> <orgName>Service de dermatologie et allergologie [CHU Tenon]</orgName> <desc> <address> <addrLine>4, rue de la Chine Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-328304" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName> <desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Le Guern, V" sort="Le Guern, V" uniqKey="Le Guern V" first="V" last="Le Guern">V. Le Guern</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192648" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-301664" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Liote, F" sort="Liote, F" uniqKey="Liote F" first="F" last="Lioté">F. Lioté</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-96249" status="INCOMING"> <orgName>Service de rhumatologie</orgName> <desc> <address> <addrLine>Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300128" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Smail, A" sort="Smail, A" uniqKey="Smail A" first="A" last="Smail">A. Smail</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192642" status="INCOMING"> <orgName>Service de Néphrologie - Médecine Interne</orgName> <desc> <address> <addrLine>Amiens</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300535" type="direct"></relation> <relation active="#struct-306759" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"> <orgName>CHU Amiens-Picardie</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-306759" type="direct"><org type="institution" xml:id="struct-306759" status="INCOMING"> <orgName>Hôpital Sud</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Limal, N" sort="Limal, N" uniqKey="Limal N" first="N" last="Limal">N. Limal</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-70758" status="VALID"> <orgName>Service de médecine interne [Mondor]</orgName> <desc> <address> <addrLine>51 Av du Maréchal de Lattre de Tassigny, 94000 Créteil</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300087" type="direct"></relation> <relation active="#struct-420786" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID"> <orgName>Hôpital Henri Mondor</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-420786" type="direct"><org type="institution" xml:id="struct-420786" status="VALID"> <idno type="IdRef">028021037</idno> <idno type="ISNI">0000000121497878</idno> <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName> <orgName type="acronym">UPEC UP12</orgName> <date type="start">1970-01-01</date> <desc> <address> <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-pec.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Perard, L" sort="Perard, L" uniqKey="Perard L" first="L" last="Perard">L. Perard</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139421" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <addrLine>Centre hospitalier Lyon Sud</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300074" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300074" type="direct"><org type="regroupinstitution" xml:id="struct-300074" status="VALID"> <idno type="IdRef">026534657</idno> <orgName>Hospices Civils de Lyon</orgName> <orgName type="acronym">HCL</orgName> <desc> <address> <addrLine>3 Quai des Célestins69002 Lyon </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Desmurs Clavel, H" sort="Desmurs Clavel, H" uniqKey="Desmurs Clavel H" first="H" last="Desmurs-Clavel">H. Desmurs-Clavel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139421" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <addrLine>Centre hospitalier Lyon Sud</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300074" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300074" type="direct"><org type="regroupinstitution" xml:id="struct-300074" status="VALID"> <idno type="IdRef">026534657</idno> <orgName>Hospices Civils de Lyon</orgName> <orgName type="acronym">HCL</orgName> <desc> <address> <addrLine>3 Quai des Célestins69002 Lyon </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Le Thi Huong, D" sort="Le Thi Huong, D" uniqKey="Le Thi Huong D" first="D" last="Le Thi Huong">D. Le Thi Huong</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Asli, B" sort="Asli, B" uniqKey="Asli B" first="B" last="Asli">B. Asli</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-212052" status="OLD"> <orgName>Service d'Immunopathologie [Hôpital Saint-Louis, Paris]</orgName> <date type="end">2019-12-31</date> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300301" type="direct"></relation> <relation active="#struct-523767" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-523767" type="direct"><org type="institution" xml:id="struct-523767" status="VALID"> <orgName>CHU Saint Louis [APHP]</orgName> <desc> <address> <addrLine>Hôpital Saint Louis,1 avenue Claude Vellefaux75010 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Kahn, J E" sort="Kahn, J E" uniqKey="Kahn J" first="J-E" last="Kahn">J-E Kahn</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-450475" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <orgName type="acronym">Med Int - Hôpital Foch</orgName> <desc> <address> <addrLine>Universite Versailles Saint Quentin en Yvelines, Service de Medecine Interne, Hopital Foch, 4a rue Worth, 92150 Suresnes, FranceFaculte de Medecine, Universite Paris-Sud; Hopitaux Universitaires Paris-Sud, Le Kremlin Bicetre, AP-HP, France.</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-410109" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-410109" type="direct"><org type="institution" xml:id="struct-410109" status="VALID"> <orgName>Hôpital Foch [Suresnes]</orgName> <desc> <address> <addrLine>40 Rue Worth 92150 Suresnes</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hopital-foch.com/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pourrat, J" sort="Pourrat, J" uniqKey="Pourrat J" first="J" last="Pourrat">J. Pourrat</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192646" status="VALID"> <orgName>Service de Néphrologie - Immunologie Clinique [Toulouse]</orgName> <desc> <address> <addrLine>1, avenue du Professeur Jean Poulhès - TSA 50032 - 31059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> <relation active="#struct-300791" type="direct"></relation> <relation active="#struct-301089" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300075" type="direct"><org type="regroupinstitution" xml:id="struct-300075" status="VALID"> <orgName>CHU Toulouse [Toulouse]</orgName> <desc> <address> <addrLine>Hôtel-Dieu Saint Jacques2, rue ViguerieTSA 8003531059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300791" type="direct"><org type="institution" xml:id="struct-300791" status="VALID"> <orgName>Hôpital de Rangueil</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301089" type="direct"><org type="institution" xml:id="struct-301089" status="OLD"> <orgName>PRES Université de Toulouse</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sailler, L" sort="Sailler, L" uniqKey="Sailler L" first="L" last="Sailler">L. Sailler</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101805" status="INCOMING"> <orgName>Service de Medecine Interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> <relation active="#struct-300779" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300075" type="direct"><org type="regroupinstitution" xml:id="struct-300075" status="VALID"> <orgName>CHU Toulouse [Toulouse]</orgName> <desc> <address> <addrLine>Hôtel-Dieu Saint Jacques2, rue ViguerieTSA 8003531059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300779" type="direct"><org type="institution" xml:id="struct-300779" status="VALID"> <orgName>Hôpital Purpan [Toulouse]</orgName> <desc> <address> <addrLine>Place du Docteur BaylacTSA 4003131059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-toulouse.fr/-hopital-purpan-</ref> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> </listRelation> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Ackermann, F" sort="Ackermann, F" uniqKey="Ackermann F" first="F" last="Ackermann">F. Ackermann</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-450475" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <orgName type="acronym">Med Int - Hôpital Foch</orgName> <desc> <address> <addrLine>Universite Versailles Saint Quentin en Yvelines, Service de Medecine Interne, Hopital Foch, 4a rue Worth, 92150 Suresnes, FranceFaculte de Medecine, Universite Paris-Sud; Hopitaux Universitaires Paris-Sud, Le Kremlin Bicetre, AP-HP, France.</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-410109" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-410109" type="direct"><org type="institution" xml:id="struct-410109" status="VALID"> <orgName>Hôpital Foch [Suresnes]</orgName> <desc> <address> <addrLine>40 Rue Worth 92150 Suresnes</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hopital-foch.com/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Papo, T" sort="Papo, T" uniqKey="Papo T" first="T" last="Papo">T. Papo</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-26728" status="INCOMING"> <orgName>Hôpital Bichat - Claude Bernard</orgName> <desc> <address> <addrLine>46, rue Henri-Huchard 75018 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sacre, K" sort="Sacre, K" uniqKey="Sacre K" first="K" last="Sacré">K. Sacré</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-26728" status="INCOMING"> <orgName>Hôpital Bichat - Claude Bernard</orgName> <desc> <address> <addrLine>46, rue Henri-Huchard 75018 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fain, O" sort="Fain, O" uniqKey="Fain O" first="O" last="Fain">O. Fain</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID"> <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName> <orgName type="acronym">DHU i2B </orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-454982" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Stirnemann, J" sort="Stirnemann, J" uniqKey="Stirnemann J" first="J" last="Stirnemann">J. Stirnemann</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-450476" status="INCOMING"> <orgName>Department of General Medicine</orgName> <orgName type="acronym">Dep Gen Med - GENEVE</orgName> <desc> <address> <addrLine>Department of General Internal Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, CH-1211, Geneve 14, Switzerland.</addrLine> <country key="CH"></country> </address> </desc> <listRelation> <relation active="#struct-305734" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-305734" type="direct"><org type="institution" xml:id="struct-305734" status="VALID"> <orgName>Hôpitaux Universitaires de Genève</orgName> <orgName type="acronym">HUG</orgName> <desc> <address> <addrLine>Rue Gabrielle-Perret-Gentil 4,1205 Genève</addrLine> <country key="CH"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Suisse</country></affiliation></author><author><name sortKey="Cacoub, P" sort="Cacoub, P" uniqKey="Cacoub P" first="P" last="Cacoub">P. Cacoub</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-247283" status="OLD"> <idno type="RNSR">200918530G</idno> <orgName>Immunologie - Immunopathologie - Immunothérapie</orgName> <orgName type="acronym">I3</orgName> <desc> <address> <addrLine>Bâtiment CERVI, CHU Pitié-Salpêtrière 83 boulevard de l'Hôpital 75651 Paris Cedex 13 (France)</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR7211" active="#struct-441569" type="direct"></relation> <relation name="U959" active="#struct-303623" type="direct"></relation> <relation active="#struct-93591" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR7211" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U959" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Leroux, G" sort="Leroux, G" uniqKey="Leroux G" first="G" last="Leroux">G. Leroux</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cohen Bittan, J" sort="Cohen Bittan, J" uniqKey="Cohen Bittan J" first="J" last="Cohen-Bittan">J. Cohen-Bittan</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-424526" status="VALID"> <orgName>Unité péri-opératoire gériatrique [Paris]</orgName> <desc> <address> <addrLine>Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sellam, J" sort="Sellam, J" uniqKey="Sellam J" first="J" last="Sellam">J. Sellam</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID"> <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName> <orgName type="acronym">DHU i2B </orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-454982" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mariette, X" sort="Mariette, X" uniqKey="Mariette X" first="X" last="Mariette">X. Mariette</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106183" status="VALID"> <orgName>Régulation de la réponse immune, infection VIH-1 et autoimmunité</orgName> <desc> <address> <addrLine>63, rue Gabriel Péri, 94276 Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92966" type="direct"></relation> <relation name="U1012" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID"> <orgName>Université Paris-Sud - Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc> </org></tutelle><tutelle name="U1012" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Blanchet, B" sort="Blanchet, B" uniqKey="Blanchet B" first="B" last="Blanchet">B. Blanchet</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Hulot, J S" sort="Hulot, J S" uniqKey="Hulot J" first="J S" last="Hulot">J S Hulot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-428299" status="INCOMING"> <orgName>UF pharmacologie et pharmacogénétique</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Piette, J C" sort="Piette, J C" uniqKey="Piette J" first="J C" last="Piette">J C Piette</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Costedoat Chalumeau, N" sort="Costedoat Chalumeau, N" uniqKey="Costedoat Chalumeau N" first="N" last="Costedoat-Chalumeau">N. Costedoat-Chalumeau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192648" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-301664" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Delluc, Aurelien" sort="Delluc, Aurelien" uniqKey="Delluc A" first="Aurelien" last="Delluc">Aurelien Delluc</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-102913" status="VALID"> <orgName>Département de Médecine Interne et Pneumologie [Brest]</orgName> <orgName type="acronym">DMIP - Brest</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.chu-brest.fr/web/guest/pneumologie</ref> </desc> <listRelation> <relation active="#struct-356603" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-356603" type="direct"><org type="institution" xml:id="struct-356603" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire de Brest</orgName> <orgName type="acronym">CHRU Brest</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01272718</idno><idno type="halId">hal-01272718</idno><idno type="halUri">https://hal.univ-brest.fr/hal-01272718</idno><idno type="url">https://hal.univ-brest.fr/hal-01272718</idno><idno type="doi">10.1002/art.39194</idno><date when="2015-04-30">2015-04-30</date><idno type="wicri:Area/Hal/Corpus">000070</idno><idno type="wicri:Area/Hal/Curation">000070</idno><idno type="wicri:Area/Hal/Checkpoint">000096</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000096</idno><idno type="wicri:doubleKey">2326-5205:2015:Jallouli M:determinants:of:hydroxychloroquine</idno><idno type="wicri:Area/Main/Merge">000E50</idno><idno type="wicri:Area/Main/Curation">000E49</idno><idno type="wicri:Area/Main/Exploration">000E49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus.</title><author><name sortKey="Jallouli, M" sort="Jallouli, M" uniqKey="Jallouli M" first="M" last="Jallouli">M. Jallouli</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192648" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-301664" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Galicier, L" sort="Galicier, L" uniqKey="Galicier L" first="L" last="Galicier">L. Galicier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-212052" status="OLD"> <orgName>Service d'Immunopathologie [Hôpital Saint-Louis, Paris]</orgName> <date type="end">2019-12-31</date> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300301" type="direct"></relation> <relation active="#struct-523767" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-523767" type="direct"><org type="institution" xml:id="struct-523767" status="VALID"> <orgName>CHU Saint Louis [APHP]</orgName> <desc> <address> <addrLine>Hôpital Saint Louis,1 avenue Claude Vellefaux75010 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Zahr, N" sort="Zahr, N" uniqKey="Zahr N" first="N" last="Zahr">N. Zahr</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-428299" status="INCOMING"> <orgName>UF pharmacologie et pharmacogénétique</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Aumaitre, O" sort="Aumaitre, O" uniqKey="Aumaitre O" first="O" last="Aumaître">O. Aumaître</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-232091" status="INCOMING"> <orgName>Service de médecine interne, hôpital Gabriel-Montpied</orgName> <desc> <address> <addrLine>Service de médecine interne, hôpital Gabriel-Montpied, 58, rue Montalembert, 63003 Clermont-Ferrand cedex 1, France</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300144" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300144" type="direct"><org type="institution" xml:id="struct-300144" status="VALID"> <orgName>CHU Clermont-Ferrand</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Frances, C" sort="Frances, C" uniqKey="Frances C" first="C" last="Francès">C. Francès</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19449" status="OLD"> <orgName>Service de dermatologie et allergologie [CHU Tenon]</orgName> <desc> <address> <addrLine>4, rue de la Chine Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-328304" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID"> <orgName>CHU Tenon [APHP]</orgName> <desc> <address> <addrLine>4 Rue de la Chine, 75020 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Le Guern, V" sort="Le Guern, V" uniqKey="Le Guern V" first="V" last="Le Guern">V. Le Guern</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192648" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-301664" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Liote, F" sort="Liote, F" uniqKey="Liote F" first="F" last="Lioté">F. Lioté</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-96249" status="INCOMING"> <orgName>Service de rhumatologie</orgName> <desc> <address> <addrLine>Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300128" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Smail, A" sort="Smail, A" uniqKey="Smail A" first="A" last="Smail">A. Smail</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192642" status="INCOMING"> <orgName>Service de Néphrologie - Médecine Interne</orgName> <desc> <address> <addrLine>Amiens</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300535" type="direct"></relation> <relation active="#struct-306759" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"> <orgName>CHU Amiens-Picardie</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-306759" type="direct"><org type="institution" xml:id="struct-306759" status="INCOMING"> <orgName>Hôpital Sud</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Limal, N" sort="Limal, N" uniqKey="Limal N" first="N" last="Limal">N. Limal</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-70758" status="VALID"> <orgName>Service de médecine interne [Mondor]</orgName> <desc> <address> <addrLine>51 Av du Maréchal de Lattre de Tassigny, 94000 Créteil</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300087" type="direct"></relation> <relation active="#struct-420786" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300087" type="direct"><org type="institution" xml:id="struct-300087" status="VALID"> <orgName>Hôpital Henri Mondor</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-420786" type="direct"><org type="institution" xml:id="struct-420786" status="VALID"> <idno type="IdRef">028021037</idno> <idno type="ISNI">0000000121497878</idno> <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName> <orgName type="acronym">UPEC UP12</orgName> <date type="start">1970-01-01</date> <desc> <address> <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-pec.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Perard, L" sort="Perard, L" uniqKey="Perard L" first="L" last="Perard">L. Perard</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139421" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <addrLine>Centre hospitalier Lyon Sud</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300074" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300074" type="direct"><org type="regroupinstitution" xml:id="struct-300074" status="VALID"> <idno type="IdRef">026534657</idno> <orgName>Hospices Civils de Lyon</orgName> <orgName type="acronym">HCL</orgName> <desc> <address> <addrLine>3 Quai des Célestins69002 Lyon </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Desmurs Clavel, H" sort="Desmurs Clavel, H" uniqKey="Desmurs Clavel H" first="H" last="Desmurs-Clavel">H. Desmurs-Clavel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139421" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <addrLine>Centre hospitalier Lyon Sud</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300074" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300074" type="direct"><org type="regroupinstitution" xml:id="struct-300074" status="VALID"> <idno type="IdRef">026534657</idno> <orgName>Hospices Civils de Lyon</orgName> <orgName type="acronym">HCL</orgName> <desc> <address> <addrLine>3 Quai des Célestins69002 Lyon </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Le Thi Huong, D" sort="Le Thi Huong, D" uniqKey="Le Thi Huong D" first="D" last="Le Thi Huong">D. Le Thi Huong</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Asli, B" sort="Asli, B" uniqKey="Asli B" first="B" last="Asli">B. Asli</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-212052" status="OLD"> <orgName>Service d'Immunopathologie [Hôpital Saint-Louis, Paris]</orgName> <date type="end">2019-12-31</date> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300301" type="direct"></relation> <relation active="#struct-523767" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-523767" type="direct"><org type="institution" xml:id="struct-523767" status="VALID"> <orgName>CHU Saint Louis [APHP]</orgName> <desc> <address> <addrLine>Hôpital Saint Louis,1 avenue Claude Vellefaux75010 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Kahn, J E" sort="Kahn, J E" uniqKey="Kahn J" first="J-E" last="Kahn">J-E Kahn</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-450475" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <orgName type="acronym">Med Int - Hôpital Foch</orgName> <desc> <address> <addrLine>Universite Versailles Saint Quentin en Yvelines, Service de Medecine Interne, Hopital Foch, 4a rue Worth, 92150 Suresnes, FranceFaculte de Medecine, Universite Paris-Sud; Hopitaux Universitaires Paris-Sud, Le Kremlin Bicetre, AP-HP, France.</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-410109" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-410109" type="direct"><org type="institution" xml:id="struct-410109" status="VALID"> <orgName>Hôpital Foch [Suresnes]</orgName> <desc> <address> <addrLine>40 Rue Worth 92150 Suresnes</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hopital-foch.com/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pourrat, J" sort="Pourrat, J" uniqKey="Pourrat J" first="J" last="Pourrat">J. Pourrat</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192646" status="VALID"> <orgName>Service de Néphrologie - Immunologie Clinique [Toulouse]</orgName> <desc> <address> <addrLine>1, avenue du Professeur Jean Poulhès - TSA 50032 - 31059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> <relation active="#struct-300791" type="direct"></relation> <relation active="#struct-301089" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300075" type="direct"><org type="regroupinstitution" xml:id="struct-300075" status="VALID"> <orgName>CHU Toulouse [Toulouse]</orgName> <desc> <address> <addrLine>Hôtel-Dieu Saint Jacques2, rue ViguerieTSA 8003531059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300791" type="direct"><org type="institution" xml:id="struct-300791" status="VALID"> <orgName>Hôpital de Rangueil</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301089" type="direct"><org type="institution" xml:id="struct-301089" status="OLD"> <orgName>PRES Université de Toulouse</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sailler, L" sort="Sailler, L" uniqKey="Sailler L" first="L" last="Sailler">L. Sailler</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101805" status="INCOMING"> <orgName>Service de Medecine Interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> <relation active="#struct-300779" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300075" type="direct"><org type="regroupinstitution" xml:id="struct-300075" status="VALID"> <orgName>CHU Toulouse [Toulouse]</orgName> <desc> <address> <addrLine>Hôtel-Dieu Saint Jacques2, rue ViguerieTSA 8003531059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300779" type="direct"><org type="institution" xml:id="struct-300779" status="VALID"> <orgName>Hôpital Purpan [Toulouse]</orgName> <desc> <address> <addrLine>Place du Docteur BaylacTSA 4003131059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-toulouse.fr/-hopital-purpan-</ref> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> </listRelation> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Ackermann, F" sort="Ackermann, F" uniqKey="Ackermann F" first="F" last="Ackermann">F. Ackermann</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-450475" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <orgName type="acronym">Med Int - Hôpital Foch</orgName> <desc> <address> <addrLine>Universite Versailles Saint Quentin en Yvelines, Service de Medecine Interne, Hopital Foch, 4a rue Worth, 92150 Suresnes, FranceFaculte de Medecine, Universite Paris-Sud; Hopitaux Universitaires Paris-Sud, Le Kremlin Bicetre, AP-HP, France.</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-410109" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-410109" type="direct"><org type="institution" xml:id="struct-410109" status="VALID"> <orgName>Hôpital Foch [Suresnes]</orgName> <desc> <address> <addrLine>40 Rue Worth 92150 Suresnes</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hopital-foch.com/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Papo, T" sort="Papo, T" uniqKey="Papo T" first="T" last="Papo">T. Papo</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-26728" status="INCOMING"> <orgName>Hôpital Bichat - Claude Bernard</orgName> <desc> <address> <addrLine>46, rue Henri-Huchard 75018 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sacre, K" sort="Sacre, K" uniqKey="Sacre K" first="K" last="Sacré">K. Sacré</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-26728" status="INCOMING"> <orgName>Hôpital Bichat - Claude Bernard</orgName> <desc> <address> <addrLine>46, rue Henri-Huchard 75018 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fain, O" sort="Fain, O" uniqKey="Fain O" first="O" last="Fain">O. Fain</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID"> <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName> <orgName type="acronym">DHU i2B </orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-454982" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Stirnemann, J" sort="Stirnemann, J" uniqKey="Stirnemann J" first="J" last="Stirnemann">J. Stirnemann</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-450476" status="INCOMING"> <orgName>Department of General Medicine</orgName> <orgName type="acronym">Dep Gen Med - GENEVE</orgName> <desc> <address> <addrLine>Department of General Internal Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, CH-1211, Geneve 14, Switzerland.</addrLine> <country key="CH"></country> </address> </desc> <listRelation> <relation active="#struct-305734" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-305734" type="direct"><org type="institution" xml:id="struct-305734" status="VALID"> <orgName>Hôpitaux Universitaires de Genève</orgName> <orgName type="acronym">HUG</orgName> <desc> <address> <addrLine>Rue Gabrielle-Perret-Gentil 4,1205 Genève</addrLine> <country key="CH"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Suisse</country></affiliation></author><author><name sortKey="Cacoub, P" sort="Cacoub, P" uniqKey="Cacoub P" first="P" last="Cacoub">P. Cacoub</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-247283" status="OLD"> <idno type="RNSR">200918530G</idno> <orgName>Immunologie - Immunopathologie - Immunothérapie</orgName> <orgName type="acronym">I3</orgName> <desc> <address> <addrLine>Bâtiment CERVI, CHU Pitié-Salpêtrière 83 boulevard de l'Hôpital 75651 Paris Cedex 13 (France)</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR7211" active="#struct-441569" type="direct"></relation> <relation name="U959" active="#struct-303623" type="direct"></relation> <relation active="#struct-93591" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR7211" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U959" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Leroux, G" sort="Leroux, G" uniqKey="Leroux G" first="G" last="Leroux">G. Leroux</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cohen Bittan, J" sort="Cohen Bittan, J" uniqKey="Cohen Bittan J" first="J" last="Cohen-Bittan">J. Cohen-Bittan</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-424526" status="VALID"> <orgName>Unité péri-opératoire gériatrique [Paris]</orgName> <desc> <address> <addrLine>Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sellam, J" sort="Sellam, J" uniqKey="Sellam J" first="J" last="Sellam">J. Sellam</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID"> <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName> <orgName type="acronym">DHU i2B </orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-454982" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mariette, X" sort="Mariette, X" uniqKey="Mariette X" first="X" last="Mariette">X. Mariette</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106183" status="VALID"> <orgName>Régulation de la réponse immune, infection VIH-1 et autoimmunité</orgName> <desc> <address> <addrLine>63, rue Gabriel Péri, 94276 Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92966" type="direct"></relation> <relation name="U1012" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID"> <orgName>Université Paris-Sud - Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc> </org></tutelle><tutelle name="U1012" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Blanchet, B" sort="Blanchet, B" uniqKey="Blanchet B" first="B" last="Blanchet">B. Blanchet</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Hulot, J S" sort="Hulot, J S" uniqKey="Hulot J" first="J S" last="Hulot">J S Hulot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-428299" status="INCOMING"> <orgName>UF pharmacologie et pharmacogénétique</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Piette, J C" sort="Piette, J C" uniqKey="Piette J" first="J C" last="Piette">J C Piette</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Costedoat Chalumeau, N" sort="Costedoat Chalumeau, N" uniqKey="Costedoat Chalumeau N" first="N" last="Costedoat-Chalumeau">N. Costedoat-Chalumeau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192648" status="INCOMING"> <orgName>Service de Médecine Interne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-301664" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Delluc, Aurelien" sort="Delluc, Aurelien" uniqKey="Delluc A" first="Aurelien" last="Delluc">Aurelien Delluc</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-102913" status="VALID"> <orgName>Département de Médecine Interne et Pneumologie [Brest]</orgName> <orgName type="acronym">DMIP - Brest</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.chu-brest.fr/web/guest/pneumologie</ref> </desc> <listRelation> <relation active="#struct-356603" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-356603" type="direct"><org type="institution" xml:id="struct-356603" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire de Brest</orgName> <orgName type="acronym">CHRU Brest</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1002/art.39194</idno><series><title level="j">Arthritis & rheumatology</title><idno type="ISSN">2326-5205</idno><imprint><date type="datePub">2015-04-30</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. Therefore, interest in blood HCQ concentration measurement has increased, but little is known about factors that influence blood HCQ concentration variability. This study was undertaken to analyze determinants of blood HCQ concentrations. We conducted a retrospective analysis of patient data, including data from the Plaquenil Lupus Systemic (PLUS) study, to determine the association of epidemiologic, clinical, and biologic factors with blood HCQ concentrations. Data for nonadherent patients (blood HCQ concentration <200 ng/ml) were excluded. To examine homogeneous pharmacologic data, we restricted the analyses of the PLUS data to the 509 SLE patients receiving 400 mg/day. We found no association of ethnicity or smoking with blood HCQ concentrations and no pharmacokinetic drug-drug interaction with antacids or with inhibitors or inducers of cytochrome P450 enzymes. On multivariate analysis, high body mass index (P = 0.008), no treatment with corticosteroids (P = 0.04), increased time between the last tablet intake and measurement of blood HCQ concentrations (P = 0.017), low platelet count (P < 0.001), low neutrophil count (P < 0.001), and high estimated creatinine clearance (P < 0.001) were associated with low blood HCQ concentrations. In 22 SLE patients with chronic renal insufficiency (median serum creatinine clearance 52 ml/minute [range 23-58 ml/minute]) who received 400 mg/day HCQ, the median blood HCQ concentration was significantly higher than that in the 509 patients from the PLUS study (1,338 ng/ml [range 504-2,229 ng/ml] versus 917 ng/ml [range 208-3316 ng/ml]) (P < 0.001). We provide a comprehensive analysis of determinants of blood HCQ concentrations. Because this measurement is increasingly being used, these data might be useful for clinicians. </p> </div></front></TEI><affiliations><list><country><li>France</li><li>Suisse</li></country></list><tree><country name="France"><noRegion><name sortKey="Jallouli, M" sort="Jallouli, M" uniqKey="Jallouli M" first="M" last="Jallouli">M. Jallouli</name></noRegion><name sortKey="Ackermann, F" sort="Ackermann, F" uniqKey="Ackermann F" first="F" last="Ackermann">F. Ackermann</name><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><name sortKey="Asli, B" sort="Asli, B" uniqKey="Asli B" first="B" last="Asli">B. Asli</name><name sortKey="Aumaitre, O" sort="Aumaitre, O" uniqKey="Aumaitre O" first="O" last="Aumaître">O. Aumaître</name><name sortKey="Blanchet, B" sort="Blanchet, B" uniqKey="Blanchet B" first="B" last="Blanchet">B. Blanchet</name><name sortKey="Cacoub, P" sort="Cacoub, P" uniqKey="Cacoub P" first="P" last="Cacoub">P. Cacoub</name><name sortKey="Cohen Bittan, J" sort="Cohen Bittan, J" uniqKey="Cohen Bittan J" first="J" last="Cohen-Bittan">J. Cohen-Bittan</name><name sortKey="Costedoat Chalumeau, N" sort="Costedoat Chalumeau, N" uniqKey="Costedoat Chalumeau N" first="N" last="Costedoat-Chalumeau">N. Costedoat-Chalumeau</name><name sortKey="Delluc, Aurelien" sort="Delluc, Aurelien" uniqKey="Delluc A" first="Aurelien" last="Delluc">Aurelien Delluc</name><name sortKey="Desmurs Clavel, H" sort="Desmurs Clavel, H" uniqKey="Desmurs Clavel H" first="H" last="Desmurs-Clavel">H. Desmurs-Clavel</name><name sortKey="Fain, O" sort="Fain, O" uniqKey="Fain O" first="O" last="Fain">O. Fain</name><name sortKey="Frances, C" sort="Frances, C" uniqKey="Frances C" first="C" last="Francès">C. Francès</name><name sortKey="Galicier, L" sort="Galicier, L" uniqKey="Galicier L" first="L" last="Galicier">L. Galicier</name><name sortKey="Hulot, J S" sort="Hulot, J S" uniqKey="Hulot J" first="J S" last="Hulot">J S Hulot</name><name sortKey="Kahn, J E" sort="Kahn, J E" uniqKey="Kahn J" first="J-E" last="Kahn">J-E Kahn</name><name sortKey="Le Guern, V" sort="Le Guern, V" uniqKey="Le Guern V" first="V" last="Le Guern">V. Le Guern</name><name sortKey="Le Thi Huong, D" sort="Le Thi Huong, D" uniqKey="Le Thi Huong D" first="D" last="Le Thi Huong">D. Le Thi Huong</name><name sortKey="Leroux, G" sort="Leroux, G" uniqKey="Leroux G" first="G" last="Leroux">G. Leroux</name><name sortKey="Limal, N" sort="Limal, N" uniqKey="Limal N" first="N" last="Limal">N. Limal</name><name sortKey="Liote, F" sort="Liote, F" uniqKey="Liote F" first="F" last="Lioté">F. Lioté</name><name sortKey="Mariette, X" sort="Mariette, X" uniqKey="Mariette X" first="X" last="Mariette">X. Mariette</name><name sortKey="Papo, T" sort="Papo, T" uniqKey="Papo T" first="T" last="Papo">T. Papo</name><name sortKey="Perard, L" sort="Perard, L" uniqKey="Perard L" first="L" last="Perard">L. Perard</name><name sortKey="Piette, J C" sort="Piette, J C" uniqKey="Piette J" first="J C" last="Piette">J C Piette</name><name sortKey="Pourrat, J" sort="Pourrat, J" uniqKey="Pourrat J" first="J" last="Pourrat">J. Pourrat</name><name sortKey="Sacre, K" sort="Sacre, K" uniqKey="Sacre K" first="K" last="Sacré">K. Sacré</name><name sortKey="Sailler, L" sort="Sailler, L" uniqKey="Sailler L" first="L" last="Sailler">L. Sailler</name><name sortKey="Sellam, J" sort="Sellam, J" uniqKey="Sellam J" first="J" last="Sellam">J. Sellam</name><name sortKey="Smail, A" sort="Smail, A" uniqKey="Smail A" first="A" last="Smail">A. Smail</name><name sortKey="Zahr, N" sort="Zahr, N" uniqKey="Zahr N" first="N" last="Zahr">N. Zahr</name></country><country name="Suisse"><noRegion><name sortKey="Stirnemann, J" sort="Stirnemann, J" uniqKey="Stirnemann J" first="J" last="Stirnemann">J. Stirnemann</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E49 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E49 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Hal:hal-01272718
|texte= Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus.
}}
| This area was generated with Dilib version V0.6.33. |  |